chemoresistant hose uk

Intrinsic chemotherapy resistance to the tubulin‐binding …

Abstract Renal cancer is one of the most chemoresistant tumor types. Using a panel of 10 established renal cancer cell lines that have not been subjected to prior drug selection, the range of funct Renal cancer accounts for 2–3% of malignancies, 1 and the majority of renal cell carcinoma (RCC) are of conventional (clear cell) type. . These are thought to arise from the renal proximal

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DHFR and MDR1 upregulation is associated with …

The chemoresistant properties of CSCs have been associated with the expression of Oct-4 and Nanog (32–36). In one study, the overexpression of Nanog promoted cisplatin resistance and decreased the proportion of apoptotic cells in esophageal cancer cells ().

iASPP and Chemoresistance in Ovarian Cancers: Effects …

Abstract Purpose: iASPP is a specific regulator of p53-mediated apoptosis. Herein, we provided the first report on the expression profile of iASPP in ovarian epithelial tumor and its effect on paclitaxel chemosensitivity. Experimental Design: Expression and amplifiion status of iASPP was examined in 203 clinical samples and 17 cell lines using immunohistochemistry, quantitative real-time

Free Full-Text | More Than Resveratrol: New Insights into …

The concept of a scaffold concerns many aspects at different steps on the drug development path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point for the design of the structure dedied to specific molecular targets. For many years, the chemical uniqueness of the stilbene structure has inspired scientists from different fields such as

Hormone receptor expression profile of low-grade serous ovarian …

Hormone receptor expression profile of low-grade serous ovarian cancers Marianna Buttarellia, Floriana Mascilinib,GianFrancoZannonic, Alessandra Ciuccia,EnricaMartinellia, Flavia Filippetti a, Giovanni Scaiab, Gabriella Ferrandinab,d,1, Daniela Galloa,⁎,1 a Unit of Translational Medicine for Women and Children Health, Department of Obstetrics and Gynecology, holic University of the

Cancer Stem Cells: The Players of Immune Evasion from …

Saini V, Hose CD, Monks A, Nagashima K, Han B, Newton DL, Millione A, Shah J, Hollingshead MG, Hite KM, Burkett MW, Delosh RM, Silvers TE, Scudiero DA, Shoemaker RH. Identifiion of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.

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Could Hair Loss be a Relevant Symptom Associated with Chikungunya Danúbia Sá-Caputo, Laisa Liane Paineiras Domingos, Eliane O Guedes-Aguiar, Rafaelle P. Carvalho-Lima, Severo de Paoli, Danielle Soares Morel, Igor Bastos, Clailson H. A. Farias, Claudia F

Expression of miR-146a in patients with ovarian cancer …

A total of 27 patients were identified to be chemosensitive and 21 patients were recognized as chemoresistant. (HOSE) cells. Similarly, Cui et al detected downregulation of miR-146a in OVCAR3, CAOV3 and HEY ovarian cancer epithelial cells compared To

Targeting the Bone Marrow Microenvironment | …

Abstract Unprecedented advances in multiple myeloma (MM) therapy during the last 15 years are predominantly based on our increasing understanding of the pathophysiologic role of the bone marrow (BM) microenvironment. Indeed, new treatment paradigms, which

iASPP and Chemoresistance in Ovarian Cancers: Effects on …

Type Culture Collection. The 2 HOSE cell lines and OVCA 420 were kindly provided by Prof. G.S.W. Tsao (Depart-ment of Anatomy, the University of Hong Kong). OC316, DOV13, ES2, PA-1, TOV21G, TOV112D, and SKOV-TR were generous gifts from Dr

Expression of miR-146a in patients with ovarian cancer …

A total of 27 patients were identified to be chemosensitive and 21 patients were recognized as chemoresistant. (HOSE) cells. Similarly, Cui et al detected downregulation of miR-146a in OVCAR3, CAOV3 and HEY ovarian cancer epithelial cells compared To

The interaction between C35 and Δ Np73 promotes …

Sasaki H, Sheng Y, Kotsuji F, Tsang BK (2000) Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60 (20): 5659

Hormone receptor expression profile of low-grade serous …

Low-grade serous ovarian carcinomas (LGSOCs) are a histological subtype of epithelial ovarian tumors, accounting for fewer than 5% of all cases of ovarian carcinoma. Due to the chemoresistant nature of this subtype a search for more effective systemic therapies is actively ongoing, hormonal therapy showing some degree of activity in this clinical setting. The present study ought to investigate

MEDICIS REPORT

ORPHAN DRUGS IN ASIA 2017 Guidelines and Regulatory Requirements To Help Orphan Drug Products Enter the Asian Market Pacific Bridge Medical 7315 Wisconsin Avenue, Suite 609E Bethesda, MD 20814 Tel: (301) 469-3400 Fax: (301) 469-3409 Email

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Consistent with results of immunohistochemistry, an increase in αPIX mRNA and protein expression was detected in A2780CP, a chemoresistant cell lines, than its parental chemosensitive cell line, A2780S. Transwell migration and invasion assays revealed that

Stem cell transcription factor NANOG controls cell …

Three immortalized human normal ovarian epithelial cell lines, HOSE 6-3, HOSE 11-12 and HOSE 17-1, and 13 ovarian cancer cell lines, DOV13, ES2, OC316, …

Aurora Kinase A expression predicts platinum-resistance …

2016/5/21· High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high responsiveness to platinum-based-chemotherapy. To date, standard first-line-chemotherapy in advanced EOC includes platinum salts and paclitaxel with or without bevacizumab. …

Stem cell transcription factor NANOG controls cell …

Three immortalized human normal ovarian epithelial cell lines, HOSE 6-3, HOSE 11-12 and HOSE 17-1, and 13 ovarian cancer cell lines, DOV13, ES2, OC316, …

Ovarian Tumor Cell Expression of Claudin-4 Reduces …

Mean ± s.e.m., n=10 HOSE, n=10–53 HGSOC tumor specimens, n=7 other EOC subtypes, *p<0.05, ***p<0.0001. Claudin-4-expressing cells exhibit a reduced apoptotic response to paclitaxel. To determine whether the presence of claudin-4 in tumor cells alters the response to standardof-care chemotherapies, we examined activation of caspase-3 in response to cisplatin and paclitaxel.

iASPP and Chemoresistance in Ovarian Cancers: Effects on …

Type Culture Collection. The 2 HOSE cell lines and OVCA 420 were kindly provided by Prof. G.S.W. Tsao (Depart-ment of Anatomy, the University of Hong Kong). OC316, DOV13, ES2, PA-1, TOV21G, TOV112D, and SKOV-TR were generous gifts from Dr

The interaction between C35 and Δ Np73 promotes …

Sasaki H, Sheng Y, Kotsuji F, Tsang BK (2000) Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60 (20): 5659

Hormone receptor expression profile of low-grade serous ovarian …

Hormone receptor expression profile of low-grade serous ovarian cancers Marianna Buttarellia, Floriana Mascilinib,GianFrancoZannonic, Alessandra Ciuccia,EnricaMartinellia, Flavia Filippetti a, Giovanni Scaiab, Gabriella Ferrandinab,d,1, Daniela Galloa,⁎,1 a Unit of Translational Medicine for Women and Children Health, Department of Obstetrics and Gynecology, holic University of the

Hormone receptor expression profile of low-grade serous …

Low-grade serous ovarian carcinomas (LGSOCs) are a histological subtype of epithelial ovarian tumors, accounting for fewer than 5% of all cases of ovarian carcinoma. Due to the chemoresistant nature of this subtype a search for more effective systemic therapies is actively ongoing, hormonal therapy showing some degree of activity in this clinical setting. The present study ought to investigate

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